Interrelationship Between Visceral fat, Inflammation And Metabolic Syndrome!

The Cluster Of Visceral Fat, Inflammation And Metabolic Syndrome!

The interrelationship between inflammation, excess visceral fat, and metabolic syndrome is central to understanding many chronic diseases, especially those involving the heart, blood sugar regulation, and lipid balance. Here’s a clear breakdown of how these three are interconnected:

Visceral Fat as a Source of Chronic Inflammation

Visceral fat (fat stored around internal organs, especially in the abdomen) is biologically active.

It secretes pro-inflammatory cytokines, such as:

TNF-α (Tumour Necrosis Factor alpha)

IL-6 (Interleukin-6)

These compounds create a state of chronic low-grade inflammation in the body, unlike the acute inflammation seen in infections or injuries.

Inflammation Promotes Insulin Resistance

Chronic inflammation interferes with insulin signalling pathways.

Cytokines like TNF-α disrupt insulin receptors, making body cells less responsive to insulin.

This is a key mechanism in the development of insulin resistance, a hallmark of metabolic syndrome.

Metabolic Syndrome and Its Inflammatory Roots

Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke, and diabetes. These include:

High waist circumference (central obesity / visceral fat)

High blood pressure

Insulin resistance (high fasting blood sugar)

High triglycerides

Low HDL (good) cholesterol

Chronic inflammation exacerbates these conditions and metabolic syndrome and they in turn fuel more inflammation, creating a vicious cycle.

Breaking the Vicious Cycle

Losing weight helps reverse abdominal obesity and this helps reduce inflammation.

Adapting an anti inflammatory diet made up of whole grain cereals and pulses, fruits and vegetables, low fat milk and sea fish if possible (a diet rich in fiber, antioxidants and lean protein and omega-3 fats) helps.

Cardiovascular exercise helps reduce visceral fat and inflammation.

Medications like metformin or statins prescribed by doctors may help in some cases.

Diagnostic Clues

CRP (C-reactive protein) is elevated due to this inflammation.

Elevated hs-CRP (high-sensitivity C-reactive protein) is a marker of inflammation linked to metabolic syndrome.

Waist circumference and body composition scans can assess visceral fat.

Also read the articles ‘Abdominal Obesity, Diabetes And Heart Disease’, ‘Acute And Chronic Inflammation’ and ‘Metabolic Syndrome’.